Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol binds and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This results in a significant decrease in inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Indications to Use:
Oral, IM (acetate or succinate), and IV (succinate only):Anti-inflammatory or immunosuppressant agent in the treatment of a variety of diseases, including those of hematologic (i.e. immune thrombocytopenia, warm autoimmune hemolytic anemia), allergic, gastrointestinal (i.e. Crohn disease, ulcerative colitis), inflammatory, neoplastic, neurologic (i.e. multiple sclerosis), rheumatic (i.e. antineutrophil cytoplasmic antibody-associated vasculitis, dermatomyositis/polymyositis, giant-cell arteritis, gout (acute flare), giant cell arteritis, mixed cryoglobulinemia syndrome, polyarteritis nodosa, rheumatoid arthritis, systemic lupus erythematosus), and/or autoimmune origin.
Intra-articular or soft tissue administration (acetate only): Gout (acute flare), acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, and/or synovitis of osteoarthritis.
Intralesional administration (acetate only): Alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; and necrobiosis lipoidica diabeticorum. May be useful in cystic tumor of an aponeurosis or tendon (ganglia).
Dosage for solu medrol:
ral: 16mg to 64mg once daily or in divided doses.
IV (succinate): 40 to 125 mg/day given in a single daily dose or in divided doses; rarely, for certain conditions, may go up to 1 to 2 mg/kg/day.
IM (acetate or succinate): 40 to 60 mg as a single dose.
Intra-articular (acetate suspension): Dose ranges per manufacturer’s labeling. Specific dose is determined based upon joint size, severity of inflammation, amount of articular fluid present, and clinician judgment.
Side Effects Of Solu Medrol
The frequency of incidence of side effects has not been reported but can include the following: bradycardia, cardiac failure, cardiac arrhythmia, edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, depression, emotional lability, euphoria, headache, insomnia, malaise, meningitis, neuritis, neuropathy paraplegia, vertigo, acne, alopecia, ecchymoses, epidermal thinning, erythema, adrenal suppression, Cushing syndrome, insulin resistance, abdominal distension, bladder dysfunction, tendon rupture, myopathy, intraocular pressure, pulmonary edema, rhinitis.
Note this is not a complete list of side effects for Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol only common ones.
|Medical License Required||Yes|
|Generic Name||Methylprednisolone sodium succinate|
|Protect from Light and/or Freezing||Protect from light|
|Route of Administration||IV, IM|
|Storage Temperature||Store unreconstituted product at controlled room temperature 20º to 25ºC (68º to 77ºF)|
|Strength||125 mg, 40 mg|
|Unit of Measure||Vial|